The movie picks up right after Scorpion's Revenge where the heroes are attacked by Shao Kahn, which will force Raiden and his group of warriors into a deal to compete in a final Mortal Kombat that will determine the fate of the realms. This forces the good guys to travel to Outworld defend Earthrealm while Scorpion journeys to find the Kamidogu (a mystic relic made by the almighty Elder Gods) before it is used to bring back the mysterious One Being, who would destroy the universe.
Adult Swim宣布《瑞克和莫蒂》推出一部衍生剧:日本动画风的《Rick and Morty: The Anime》,佐野隆史(《神之塔》)执导,已获预订整季10集,被描述为一个关于“这个很棒的家庭”的新故事,独立于主线之外,但会包括《瑞克和莫蒂》的主题和事件。
佐野隆史此前打造过两部《瑞克和莫蒂》的衍生短片:《瑞克和莫蒂对抗种族灭绝者》和《瑞克和莫蒂外传姐姐遇见上帝》。